The commonly prescribed anti-depressant Zoloft has been found to affect the volume of brain matter in key areas of the brains of depressed and non depressed patients. This finding was published in the journal Neuropharmacology.
The problem is that Zoloft is administered for a variety of other conditions including OCD, PTSD, bulemia and many others, and that the effects of the changes on patients with those conditions is not known. Brain structure is crucial for cognitive health and these are disturbing findings. If you are considering medication for your depression I suggest neurofeedback training as a safe, side-effect free approach.
You can read the full study here.